What is Oral Mucositis?
- Oral mucositis (OM) is characterized by inflammation and ulceration of the soft tissues within the mouth leading to severe pain, inability to eat or speak and is widely considered the most debilitating side-effect of cancer therapy.
- Patients may progress from a solid to a liquid-only diet due to an inability to swallow and require the use of a feeding tube, which is often inserted prophylactically.
- There is currently no adequate solution on the market to treat or prevent OM. Patients are prescribed high doses of opioids to manage their severe pain and physicians frequently resort to interrupting treatment.
- Each year, more than 450,000 cases of oral mucositis are reported in the US. In particular, patients with head and neck cancers undergoing chemoradiotherapy (CRT) will experience the more severe forms of oral mucositis.
What is Photobiomodulation?
Photobiomodulation is the use of a specific dosage of light (wavelength, power and time) to stimulate biological functions, including wound healing. Photobiomodulation in the form of laser therapy has been demonstrated to be highly effective in the treatment of oral mucositis. However, this laser therapy must be operated by a trained clinician, can only treat small areas of tissue at a time, and one full treatment can take as long as 40 minutes, daily.
MuReva has developed a technology which harnesses Photobiomodulation to overcome the barriers which have limited the widespread adoption of medical lasers for the treatment of oral mucositis. Our technology delivers a safe, low-level visible light at a wavelength of 660nm and is designed to to deliver Photobiomodulation therapy to the mouth of an individual undergoing localized radiation therapy in order to reduce the severity of oral mucositis.